Fibrodysplasia ossificans progressiva is uncommon genetic disease of connective tissue characterized by congenital defects already in newborns. Clinical symptoms of that disease develop usually in the beginning of human life. The disease was displaying forms of big pain swellings. At first, the focus was to treat it like a benign tumour. Later, those swellings started to change in calcinosis. We report of the case 30-year-old woman, who was born with congenital defects characterized by distort of the fingers and feet. That disease was started in 4-5 year of old. The process of ossification walked progressively. The sharp worsening of health occurred after injury (fall of the bike). Diagnoses of downloading stretch the muscle and biopsy of muscle was performed. The diagnosis of the disease was early in 6 years of old and the treatment with etidronate sodium was unsuccessful on natural course of the disease.